Bronchodilating and cardiovascular actions of (-)-1-(3, 4, 5-trimethoxybenzyl)-5, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride (l-DTI) in the anesthetized dog
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Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines
A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...
متن کاملSynthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines
A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...
متن کاملBronchodilating actions of (+/-)-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (TMI) derivatives in anesthetized cats.
Bronchodilating actions of 7-hydroxy(l), 5,7-dihydroxy(II), 5,6,7-trihydroxy (III) and 6,7.ti-trihvdroxy(IV)-(_~ )-I-(3,4,5-trimethoxybenzyl)-12,3,4-tetrahydroiso quinolinc (TMl) sere investigated in anesthetii.ed cats and results were compared to those of AQ-110 (6,7-dih)droxy-TMI) and isoproterenol. TMI derivatives given intravenously suppressed the bronchoconstriction induced by serotonin. T...
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A decentralized failure detection and isolation (FDI) methodology, which is robust with respect to model uncertainties and noise, is presented. Redundancy metrics are developed, and optimization problems are posed for the choices of robust parity relations. Closed-form solutions for some special failure cases are given. Connections are drawn with other disciplines, and the use of the metrics to...
متن کاملMicrowave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives
New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the con...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1978
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.74.663